The calendar has turned to October and the weather is getting colder, but the injury bug has not gone to rest for the winter.
Several stars around the NFL are dealing with injuries ahead of their respective Week 6 games: quarterbacks Lamar Jackson and Kyler Murray, wide receivers Amon-Ra St. Brown, Xavier Worthy and Chris Godwin, running backs Chuba Hubbard and Bucky Irving. Several of them have already missed game time this season, while others have recently popped up on injury reports and are trying to get healthy before Sunday.
The best ability is availability. As the 2025 NFL season closes out its first third of an 18-week schedule, these seven players’ availabilities are still up in the air.
Here’s what to know, three days before Week 6’s Sunday slate:
Lamar Jackson injury update
Jackson sustained a hamstring injury in the Baltimore Ravens’ Week 4 loss to the Kansas City Chiefs and missed his team’s Week 5 game against the Houston Texans.
The two-time MVP did not practice on Wednesday, and NFL Network’s Ian Rapoport reported at the time that Jackson’s status for Week 6 was ‘very much in doubt.’ Jackson missed Thursday’s practice as well, which all but guarantees he’ll miss Sunday’s game against the Los Angeles Rams.
Jackson did not miss a game of significance in either of the last two seasons after playing 12 games each in the 2021 and 2022 seasons. The Ravens’ star quarterback has thrown for 869 yards, 10 touchdowns and one interception in his four games this season. He’s the current league leader in passer rating (130.5) and QBR (83.6).
Kyler Murray injury update
During the third quarter of last Sunday’s loss to the Tennessee Titans, Murray injured his foot after a miscommunication on a snap led to a fumble.
The Arizona Cardinals’ quarterback returned to finish out the game but has since missed practice on both Wednesday and Thursday. Rapoport said Thursday morning that Murray’s injury was not initially believed to be significant. But Murray’s absence from Thursday’s practice might suggest his status for a Sunday’ meeting with the Indianapolis Colts is in question.
Murray played in all 17 games last year after missing 15 games over the previous two seasons recovering from a torn ACL. He’s thrown for 962 yards, six touchdowns and three interceptions in five games so far this year.
Amon-Ra St. Brown injury update
St. Brown popped up on the Detroit Lions’ injury report on Wednesday with a wrist issue causing him to miss practice.
Detroit’s lead wideout returned to the practice field on Thursday, meaning he’ll likely avoid missing any time.
St. Brown most recently caught eight passes for 100 yards in the Lions’ win over the Cincinnati Bengals and leads the NFL with six touchdown receptions.
Xavier Worthy injury update
Worthy has already missed two games – and the better part of a third – after tearing his labrum in a collision with Chiefs teammate and tight end Travis Kelce. Ahead of the Chiefs’ Week 5 ‘Monday Night Football’ loss to the Jacksonville Jaguars, the former first-round receiver was also dealing with a swollen ankle but ended up playing.
Despite practicing as a full participant on Wednesday, Worthy did not practice with the rest of the team on Thursday. His status for the Chiefs’ ‘Sunday Night Football’ game against the Lions is unclear.
Worthy has recorded 11 catches for 125 yards so far this season in two full games played.
Chris Godwin injury update
The Tampa Bay Buccaneers wide receiver missed the back half of last season after sustaining a dislocated ankle in Week 7. Godwin returned to action in Week 4 of 2025 after undergoing and recovering from his surgery last year.
Tampa Bay’s veteran wideout has struggled through his two games back, posting identical lines of three catches for 26 yards in his two outings so far. Now, Godwin has popped back up on the Bucs’ injury report this week with a fibula injury ahead of Week 6.
The fibula is the smaller bone on the outside of the lower leg and makes up the ankle. Godwin’s fibula injury has kept him out of both Wednesday and Thursday practices, calling into question his status for Sunday afternoon’s clash with the San Francisco 49ers.
Chuba Hubbard injury update
The Carolina Panthers’ running back has been dealing with a calf injury since Week 4, when Hubbard was listed as a limited participant in practice on his team’s injury report.
Hubbard missed all of Week 5’s practices before the Panthers ruled him out for last Sunday’s game against the Miami Dolphins. He has since worked out to the side of Carolina’s practice sessions on both Wednesday and Thursday.
Given that Hubbard still hasn’t practiced in uniform three days from the Panthers’ meeting with the Dallas Cowboys, he’ll likely miss a second straight game. Rico Dowdle will remain Carolina’s lead back against his former team.
Bucky Irving injury update
Irving popped up on the Buccaneers’ injury report last week with foot and shoulder injuries. He missed every practice before the team ruled him out of their Week 5 game against the Seattle Seahawks.
Through two practices so far this week, Irving has yet to make his return. The Tampa Bay Times’ Buccaneers reporter, Rick Stroud, reported that he did not see the Bucs’ lead back at practice on Thursday after Irving was listed as a non-participant on Wednesday’s injury report.
Irving will likely miss a second game, meaning Rachaad White and Sean Tucker will continue to split carries out of Tampa Bay’s backfield.